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31) Thus a considerable number of cases of both ulcerative colitis and Crohn's disease are sporadic or non-genetic.

32) These data confirm the frequency of growth impairment in childhood Crohn's Disease.

33) There is now substantial evidence that vascular disruption and focal thrombosis, related to macrophage infiltration, occurs in Crohn's disease.

34) The other IgG subclasses were not correlated at the cellular level in either ulcerative colitis or Crohn's disease twins.

35) The overall probability for a patient with Crohn's disease being homozygous for the major locus for Crohn's disease was 0.07.

36) A positive reaction was seen in the bowel wall(Sentencedict.com), both in patients with Crohn's disease and in controls.

37) Granulomata themselves were comparatively infrequent, and other histological features characteristic of Crohn's disease were less conspicuous than usual.

38) All these parameters were normal in patients with Crohn's disease in remission and in controls.

39) Noeterminal ileal recurrence in those with inactive Crohn's disease was graded endoscopically.

40) A progressive reduction in tissue perfusion may accompany recurrence of Crohn's disease while at a subclinical stage.

41) In clinical trials of Crohn's disease, objective criteria of gut inflammation are desirable, particularly if quantifiable.

42) Kirschner etal, on the other hand, showed low serum IGF-I concentrations in children with Crohn's disease.

43) The importance of early recognition of Crohn's disease before it has such an adverse impact on linear growth is highlighted.

44) Originally only four patients were classified as having definite Crohn's disease and 15 as indeterminate colitis leaving 62 with ulcerative colitis.

45) She had a past history of Crohn's disease which was quiescent and she was taking oral contraceptives.

46) The biopsy from one of the nine healthy Crohn's disease twins turned out to be inadequate for immunohistochemical evaluation.

47) There have been few community based studies of mortality in Crohn's disease.

48) Ulcerative colitis and Crohn's disease are chronic, remitting and relapsing mucosal disorders, collectively known as inflammatory bowel disease.

49) There continues to be no generally accepted indicator of disease activity in Crohn's disease.

50) Seven patients with definite Crohn's disease, seven with indeterminate colitis and 52 with typical ulcerative colitis have a functioning pouch.

51) Only 14 out of 105 Crohn's disease patients showed perinuclear antineutrophil cytoplasmic antibody reactivity by indirect immunofluorescence assay.

52) Crohn's disease is commonly associated with undernutrition, which is often most evident when the disease is active.

53) Before either ulcerative colitis or Crohn's disease was diagnosed infectious and neoplastic diseases had to be ruled out.

54) The role of specific acetyltransferase activity in Crohn's disease patients has not been so far studied, and deserves investigation.

55) Inevitably patients with Crohn's disease or indeterminate colitis will from time to time have restorative proctocolectomy.

56) The poorer prognosis for linear growth among boys who develop Crohn's disease before puberty has not been previously reported.

57) The antibodies were tested in specimens obtained at bowel resection from patients with Crohn's disease and controls.

58) Discussion Our patient had Crohn's disease: the macroscopic and histological features of the oral and perianal lesions are typical.

59) Crohn's disease causes chronic gastrointestinal symptoms which may require prolonged medication and surgical intervention.

60) Despite some similarities, it seems increasingly likely that the pathogenic mechanisms of ulcerative colitis and Crohn's disease are distinct.